Phenotypic switching in gene regulatory networks
نویسندگان
چکیده
منابع مشابه
Phenotypic switching in gene regulatory networks.
Noise in gene expression can lead to reversible phenotypic switching. Several experimental studies have shown that the abundance distributions of proteins in a population of isogenic cells may display multiple distinct maxima. Each of these maxima may be associated with a subpopulation of a particular phenotype, the quantification of which is important for understanding cellular decision-making...
متن کاملSI Appendix: Phenotypic switching in gene regulatory networks
3 Slow promoter fluctuations 5 3.1 Binary promoter switching: exact solution . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3.2 General solution using the conditional LNA . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.2.1 Conditional gene product distribution . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.2.2 Distribution of promoter states . . . . . . . . . . . ....
متن کاملSwitching Gene Regulatory Networks
A fundamental question in biology is how cells change into specific cell types with unique roles throughout development. This process can be viewed as a program prescribing the system dynamics, governed by a network of genetic interactions. Recent experimental evidence suggests that these networks are not fixed but rather change their topology as cells develop. Currently, there are limited tool...
متن کاملAutomated Synthesis and Analysis of Switching Gene Regulatory Networks
Studying the gene regulatory networks (GRNs) that govern how cells change into specific cell types with unique roles throughout development is an active area of experimental research. The fate specification process can be viewed as a biological program prescribing the system dynamics, governed by a network of genetic interactions. To investigate the possibility that GRNs are not fixed but rathe...
متن کاملKey Regulatory Gene Expression in Erythroleukemia Differentiation
The characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. In this report we characterise a leukemic model, D5A1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. Cells induced with 4 mM hexamethylene bisacetamide (HMBA) caused signs...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1400049111